Stimulation of Nonclonal Hematopoiesis and Suppression of the Neoplastic Clone After Treatment With Recombinant Human Granulocyte - Macrophage
نویسندگان
چکیده
A complete hematologic remission was achieved in a patient with therapy-related preleukemia and transfusiondependent pancytopenia after treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF). The patient remained in remission for nearly 1 year despite the discontinuation of GM-CSF treatment. Several lines of evidence suggest that normal hematopoiesis was restored after GM-CSF treatment. First, the cytogenetic anomaly, which was present before GM-CSF, completely disappeared after three cycles of treatment. Cytogenetic conversion was documented by conventional karyotypic evaluation of mitotic bone marrow cell preparations as well as by premature chromosome condensation
منابع مشابه
Stimulation of Nonclonal Hematopoiesis and Suppression of the Neoplastic Clone After Treatment With Recombinant Human Granulocyte - Macrophage Colony - Stimulating
A complete hematologic remission was achieved in a patient with therapy-related preleukemia and transfusiondependent pancytopenia after treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF). The patient remained in remission for nearly 1 year despite the discontinuation of GM-CSF treatment. Several lines of evidence suggest that normal hematopoiesis was rest...
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